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cb 839  (TargetMol)


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    TargetMol cb 839
    Hyperglutaminolysis enhances arginine biosynthesis in senescent cells and aged flies. a Venn diagram of metabolites detected by LC-MS/MS-based metabolomics assay ( n = 5 per group). These metabolites are classified into three subsets: the upregulated ones in senescent NIH3T3 cells (green, H vs C UP, p ≤ 0.05, fold change ≥ 1), the downregulated ones <t>in</t> <t>CB-839</t> (1 μM, 36 hours)-treated senescent cells (red, HCB vs H DOWN, p ≤ 0.05, fold change ≤ 1), and those engaged in the “GLS-related pathway” (blue, GLS-related). 12 metabolites situated in the intersection of these 3 subsets are listed on the right side. b A sketch map of the arginine synthesis pathway linked to glutaminolysis. c – n Levels of metabolites involved in arginine synthesis detected by LC-MS/MS assays and CB-839-caursed alterations (delta levels) of these metabolites, in proliferating (Pro) and senescent (Sen) cells. These metabolites are glutamine (Gln, c , d ), arginine (Arg, e , f ), glutamate (Glu, g , h ), ammonia (NH 4 + , i , j ), aspartate (Asp, k , l ) and citrulline (Cit, m , n ). Levels of arginine, aspartate and citrulline in naturally aged ( o ) and H 2 O 2 -stressed ( p ) flies, with young and unstressed controls. Arginine ( q ) and NH 4 + ( r ) levels in the control and H 2 O 2 -stressed flies treated without or with DON (0.1 μM, 3 days). s Levels of arginine, aspartate and citrulline in wild-type and Gls -KD flies. All metabolite assays used pooled homogenates of at least 20 flies per group and were executed with three technical replicates. Histogram data are shown as mean ± SD. Student’s t-test: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, n.s . non-significant
    Cb 839, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cb 839/product/TargetMol
    Average 94 stars, based on 4 article reviews
    cb 839 - by Bioz Stars, 2026-03
    94/100 stars

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    1) Product Images from "Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation"

    Article Title: Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation

    Journal: Signal Transduction and Targeted Therapy

    doi: 10.1038/s41392-026-02576-w

    Hyperglutaminolysis enhances arginine biosynthesis in senescent cells and aged flies. a Venn diagram of metabolites detected by LC-MS/MS-based metabolomics assay ( n = 5 per group). These metabolites are classified into three subsets: the upregulated ones in senescent NIH3T3 cells (green, H vs C UP, p ≤ 0.05, fold change ≥ 1), the downregulated ones in CB-839 (1 μM, 36 hours)-treated senescent cells (red, HCB vs H DOWN, p ≤ 0.05, fold change ≤ 1), and those engaged in the “GLS-related pathway” (blue, GLS-related). 12 metabolites situated in the intersection of these 3 subsets are listed on the right side. b A sketch map of the arginine synthesis pathway linked to glutaminolysis. c – n Levels of metabolites involved in arginine synthesis detected by LC-MS/MS assays and CB-839-caursed alterations (delta levels) of these metabolites, in proliferating (Pro) and senescent (Sen) cells. These metabolites are glutamine (Gln, c , d ), arginine (Arg, e , f ), glutamate (Glu, g , h ), ammonia (NH 4 + , i , j ), aspartate (Asp, k , l ) and citrulline (Cit, m , n ). Levels of arginine, aspartate and citrulline in naturally aged ( o ) and H 2 O 2 -stressed ( p ) flies, with young and unstressed controls. Arginine ( q ) and NH 4 + ( r ) levels in the control and H 2 O 2 -stressed flies treated without or with DON (0.1 μM, 3 days). s Levels of arginine, aspartate and citrulline in wild-type and Gls -KD flies. All metabolite assays used pooled homogenates of at least 20 flies per group and were executed with three technical replicates. Histogram data are shown as mean ± SD. Student’s t-test: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, n.s . non-significant
    Figure Legend Snippet: Hyperglutaminolysis enhances arginine biosynthesis in senescent cells and aged flies. a Venn diagram of metabolites detected by LC-MS/MS-based metabolomics assay ( n = 5 per group). These metabolites are classified into three subsets: the upregulated ones in senescent NIH3T3 cells (green, H vs C UP, p ≤ 0.05, fold change ≥ 1), the downregulated ones in CB-839 (1 μM, 36 hours)-treated senescent cells (red, HCB vs H DOWN, p ≤ 0.05, fold change ≤ 1), and those engaged in the “GLS-related pathway” (blue, GLS-related). 12 metabolites situated in the intersection of these 3 subsets are listed on the right side. b A sketch map of the arginine synthesis pathway linked to glutaminolysis. c – n Levels of metabolites involved in arginine synthesis detected by LC-MS/MS assays and CB-839-caursed alterations (delta levels) of these metabolites, in proliferating (Pro) and senescent (Sen) cells. These metabolites are glutamine (Gln, c , d ), arginine (Arg, e , f ), glutamate (Glu, g , h ), ammonia (NH 4 + , i , j ), aspartate (Asp, k , l ) and citrulline (Cit, m , n ). Levels of arginine, aspartate and citrulline in naturally aged ( o ) and H 2 O 2 -stressed ( p ) flies, with young and unstressed controls. Arginine ( q ) and NH 4 + ( r ) levels in the control and H 2 O 2 -stressed flies treated without or with DON (0.1 μM, 3 days). s Levels of arginine, aspartate and citrulline in wild-type and Gls -KD flies. All metabolite assays used pooled homogenates of at least 20 flies per group and were executed with three technical replicates. Histogram data are shown as mean ± SD. Student’s t-test: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, n.s . non-significant

    Techniques Used: Liquid Chromatography with Mass Spectroscopy, Control



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    Hyperglutaminolysis enhances arginine biosynthesis in senescent cells and aged flies. a Venn diagram of metabolites detected by LC-MS/MS-based metabolomics assay ( n = 5 per group). These metabolites are classified into three subsets: the upregulated ones in senescent NIH3T3 cells (green, H vs C UP, p ≤ 0.05, fold change ≥ 1), the downregulated ones in CB-839 (1 μM, 36 hours)-treated senescent cells (red, HCB vs H DOWN, p ≤ 0.05, fold change ≤ 1), and those engaged in the “GLS-related pathway” (blue, GLS-related). 12 metabolites situated in the intersection of these 3 subsets are listed on the right side. b A sketch map of the arginine synthesis pathway linked to glutaminolysis. c – n Levels of metabolites involved in arginine synthesis detected by LC-MS/MS assays and CB-839-caursed alterations (delta levels) of these metabolites, in proliferating (Pro) and senescent (Sen) cells. These metabolites are glutamine (Gln, c , d ), arginine (Arg, e , f ), glutamate (Glu, g , h ), ammonia (NH 4 + , i , j ), aspartate (Asp, k , l ) and citrulline (Cit, m , n ). Levels of arginine, aspartate and citrulline in naturally aged ( o ) and H 2 O 2 -stressed ( p ) flies, with young and unstressed controls. Arginine ( q ) and NH 4 + ( r ) levels in the control and H 2 O 2 -stressed flies treated without or with DON (0.1 μM, 3 days). s Levels of arginine, aspartate and citrulline in wild-type and Gls -KD flies. All metabolite assays used pooled homogenates of at least 20 flies per group and were executed with three technical replicates. Histogram data are shown as mean ± SD. Student’s t-test: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, n.s . non-significant

    Journal: Signal Transduction and Targeted Therapy

    Article Title: Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation

    doi: 10.1038/s41392-026-02576-w

    Figure Lengend Snippet: Hyperglutaminolysis enhances arginine biosynthesis in senescent cells and aged flies. a Venn diagram of metabolites detected by LC-MS/MS-based metabolomics assay ( n = 5 per group). These metabolites are classified into three subsets: the upregulated ones in senescent NIH3T3 cells (green, H vs C UP, p ≤ 0.05, fold change ≥ 1), the downregulated ones in CB-839 (1 μM, 36 hours)-treated senescent cells (red, HCB vs H DOWN, p ≤ 0.05, fold change ≤ 1), and those engaged in the “GLS-related pathway” (blue, GLS-related). 12 metabolites situated in the intersection of these 3 subsets are listed on the right side. b A sketch map of the arginine synthesis pathway linked to glutaminolysis. c – n Levels of metabolites involved in arginine synthesis detected by LC-MS/MS assays and CB-839-caursed alterations (delta levels) of these metabolites, in proliferating (Pro) and senescent (Sen) cells. These metabolites are glutamine (Gln, c , d ), arginine (Arg, e , f ), glutamate (Glu, g , h ), ammonia (NH 4 + , i , j ), aspartate (Asp, k , l ) and citrulline (Cit, m , n ). Levels of arginine, aspartate and citrulline in naturally aged ( o ) and H 2 O 2 -stressed ( p ) flies, with young and unstressed controls. Arginine ( q ) and NH 4 + ( r ) levels in the control and H 2 O 2 -stressed flies treated without or with DON (0.1 μM, 3 days). s Levels of arginine, aspartate and citrulline in wild-type and Gls -KD flies. All metabolite assays used pooled homogenates of at least 20 flies per group and were executed with three technical replicates. Histogram data are shown as mean ± SD. Student’s t-test: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, n.s . non-significant

    Article Snippet: Adriamycin HCl (ADR, S1208), Bafilomycin A1 (BafA1, S1413) were purchased from Selleck (Houston, USA); ammonium chloride (NH 4 Cl) and hydrogen peroxide (H 2 O 2 ) were purchased from CHRON Chemical (Chengdu, China); 6-Diazo-5-oxo-L-nor-leucine (DON, HY-108357) was purchased from MedChemExpress (NJ, USA); CB-839 (Telaglenastat, T6797) was purchased from TargetMol (Massachusetts, USA); L-glutamine (Gln, G8540) was purchased from Merck (Darmstadt, Germany); sodium glutamate hydrate (glutamate, Glu, A602012), L-aspartic acid sodium salt monohydrate (aspartate, Asp, A601178), L-citrulline (Cit, A604057) and L-arginine (Arg, A600205) were purchased from Sangon Biotech (Shanghai, China).

    Techniques: Liquid Chromatography with Mass Spectroscopy, Control